The PPP1R1A Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to PPP1R1A. This antibody recognizes Human antigen. The PPP1R1A Antibody has been validated for the following applications: ELISA, and Western Blot.
Description
Function: Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases.
Subunit Structure: Interacts with PPP1R15A.
Post-translational Modifications: Phosphorylation of Thr-35 is required for activity.
Similarity: Belongs to the protein phosphatase inhibitor 1 family